Inhibitors of bacterial protein synthesis with sufficient selectivity to be useful in human therapy include aminoglycosides, chloramphenicol, tetracyclines, fusidic acid
Tetracyclines are a class of antibiotics that inhibit bacterial protein synthesis by binding to the 30s subunit of their ribosomes and preventing tRNA from binding
Nuclei acid analogs B
Examples of the aminoglycoside family include amikacin, gentamicin, neomycin Study with Quizlet and memorize flashcards containing terms like What happens to bacterial cells when antibiotics, such as aminoglycosides and tetracyclines, disrupt the normal function of the ribosomes?, In which phase of microbial growth are prokaryotes the most sensitive to antimicrobial agents?, In the log (exponential growth) phase, prokaryotes are
Peak and trough levels are used to titrate this medication to a safe dose
They inhibit protein synthesis by binding to the 30S subunit of the ribosome
They are particularly active against aerobic, Gram-negative bacteria
Naturally occurring tetracyclines produced by various strains of Streptomyces were first discovered in the 1940s, and several semisynthetic tetracyclines, including
β-lactam antibiotics - inhibit cell wall synthesis C
Aminoglycosides are potent, broad-spectrum antibiotics that work by inhibiting protein synthesis
PCN alternative In contrast to aminoglycosides, these drugs are bacteriostatic and inhibit protein synthesis by blocking the association of tRNAs with the ribosome during translation
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destroy peptidoglycan
Describe how each of the following inhibits protein synthesis; aminoglycosides, tetracylclines, chloramphenicol, macrolides
They bind at the nascent peptide exit tunnel and partially occlude it
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside ( sugar )